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UK audit of quantitative thyroid uptake imaging.

Jonathan C Taylor1, Anthony W Murray, David O Hall

  • 1aDepartment of Nuclear Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield bDepartment of Medical Physics and Bioengineering, University Hospitals Bristol NHS Foundation Trust, Bristol cDepartment of Medical Physics, Leeds Teaching Hospitals NHS Trust, Leeds dDepartment of Nuclear Medicine, Poole Hospital NHS Foundation Trust, Poole eDepartment of Clinical Physics and Bioengineering, University Hospitals Coventry and Warwickshire NHS Trust, Coventry fDepartment of Medical Physics, Northampton General Hospital, Northampton gLink Medical Ltd, Bramshill, UK hDepartment of Nuclear Medicine, St Luke's Hospital, Dublin, Ireland.

Nuclear Medicine Communications
|April 29, 2017
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Summary

A UK audit found most centers deviate from British Nuclear Medicine Society guidelines for thyroid uptake imaging. However, quantitative results for Tc-99m pertechnetate scans showed low variability, indicating reliable thyroid uptake measurements.

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Area of Science:

  • Nuclear medicine
  • Medical imaging
  • Quantitative analysis

Background:

  • Thyroid uptake imaging is a common diagnostic test in the UK.
  • Variability in quantitative results can impact diagnostic accuracy.
  • Adherence to established guidelines ensures consistent and reliable imaging protocols.

Purpose of the Study:

  • To assess variability in quantitative thyroid uptake imaging results across the UK.
  • To compare local imaging protocols with British Nuclear Medicine Society (BNMS) guidelines.
  • To evaluate the consistency of quantitative thyroid uptake measurements.

Main Methods:

  • A national audit involving 54 participants was conducted.
  • Participants analyzed standardized Tc-99m pertechnetate and I-123 iodide thyroid images.
  • Quantitative measures and adherence to BNMS guidelines were assessed using provided spreadsheets and image datasets.

Main Results:

  • Most centers showed noncompliance with BNMS guidelines, particularly regarding injection-site imaging.
  • Quantitative results for Tc-99m pertechnetate uptake demonstrated low inter-site and intra-site variability (CQD 0.03–0.13).
  • Higher variability was observed for I-123 iodide uptake measurements (CQD 0.17–0.25).

Conclusions:

  • Thyroid uptake imaging remains prevalent in the UK.
  • While most centers have protocol deviations from BNMS guidelines, Tc-99m pertechnetate quantitative results are consistent.
  • Further attention to guideline adherence is needed, especially for I-123 iodide imaging protocols.