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Updated: Mar 3, 2026

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
Published on: September 25, 2019
Interplay between the Hepatitis B Virus and Innate Immunity: From an Understanding to the Development of Therapeutic
Suzanne Faure-Dupuy1, Julie Lucifora2, David Durantel3
1Cancer Research Center of Lyon (CRCL), INSERM, U1052, CNRS, University of Lyon, UMR-5286, 69003 Lyon, France. suzanne.faure-dupuy@inserm.fr.
Abstract:
The hepatitis B virus (HBV) infects hepatocytes, which are the main cell type composing a human liver. However, the liver is enriched with immune cells, particularly innate cells (e.g., myeloid cells, natural killer and natural killer T-cells (NK/NKT), dendritic cells (DCs)), in resting condition. Hence, the study of the interaction between HBV and innate immune cells is instrumental to: (1) better understand the conditions of establishment and maintenance of HBV infections in this secondary lymphoid organ; (2) define the role of these innate immune cells in treatment failure and pathogenesis; and (3) design novel immune-therapeutic concepts based on the activation/restoration of innate cell functions and/or innate effectors. This review will summarize and discuss the current knowledge we have on this interplay between HBV and liver innate immunity.
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