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Through translational prospective study, the GSTP1 Ile105Val polymorphism emerges as prognostic marker in de novo

M T Delamain1, E C M Miranda1, G J Lourenço2

  • 1Hematology and Hemotherapy Center, University of Campinas, Sao Paulo, Brazil.

Blood Cancer Journal
|April 29, 2017
PubMed
Abstract

No abstract available in PubMed .

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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