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GWAS analysis of treatment resistant schizophrenia: interaction effect of childhood trauma
Arthur Koga1, Ali Bani-Fatemi1,2, Nuwan Hettige1,2
1EEG & Genetics Group, Centre for Addiction & Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada.
Aims:
In the current study, we aimed to compare the prevalence of adverse lifetime events in treatment resistant and non-treatment resistant schizophrenia in a genome-wide association study.
Materials & Methods:
Our sample consisted of 84 Caucasian participants with schizophrenia spectrum disorders, assessed cross-sectionally to collect information regarding drug effectiveness and childhood trauma. Using a genome-wide association analysis, we tested single-nucleotide polymorphisms for their association with resistance to antipsychotics defined according to American Psychiatric Association criteria. Two models were tested: a main model and an interaction model with the childhood trauma.
Results:
Our analysis failed to demonstrate a significant relationship among 1,178,234 single-nucleotide polymorphisms and treatment-resistance in both the main model and in the childhood trauma interaction model.
Conclusion:
Even though we could not find any significant association, treatment resistance has clinical relevance and it may be determined by the interaction between biological and non biological factors.
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