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Updated: Mar 3, 2026
Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model
Published on: February 8, 2022
Perfusion monitoring and intraventricular hemorrhage in preterm infants
1Division of Neonatal Medicine, Center for Maternal, Fetal and Neonatal Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan.
Insights
Cardiovascular instability in preterm infants is linked to intraventricular hemorrhage (IVH). Novel perfusion markers, not just blood pressure, may help predict and manage IVH risk.
Area of Science:
- Neonatal Medicine
- Cardiovascular Physiology
- Neuroprotection
Background:
- Cardiovascular instability in preterm infants is a known risk factor for intraventricular hemorrhage (IVH).
- Previous strategies targeting hypotension to prevent IVH have shown limited success.
- Emerging perfusion markers offer new insights into cardiovascular regulation in neonates.
Purpose of the Study:
- To review the correlation between intraventricular hemorrhage (IVH) and cardiovascular perfusion markers in preterm infants.
- To evaluate the potential of novel perfusion markers in managing cardiovascular stability and preventing IVH.
- To provide an overview of current research on perfusion monitoring for IVH risk stratification.
Main Methods:
- Literature review of studies examining cardiovascular parameters and IVH in preterm neonates.
- Analysis of research on conventional hemodynamic monitoring (e.g., blood pressure).
- Evaluation of studies investigating novel perfusion markers (e.g., near-infrared spectroscopy, cerebral oximetry).
Main Results:
- Hypotension and blood pressure fluctuations are associated with IVH, but interventions targeting these have not been fully effective.
- Several novel perfusion markers show a correlation with the development of IVH.
- These markers may offer a more nuanced understanding of cerebral perfusion than traditional measures.
Conclusions:
- Novel perfusion markers represent a promising area for improving cardiovascular management in preterm infants at risk for IVH.
- Further research is needed to validate these markers for clinical use in predicting and preventing IVH.
- Integrating novel perfusion monitoring could enhance neuroprotection strategies for vulnerable neonates.
Abstract:
Cardiovascular instability in preterm infants during the early postnatal period correlates with the development of intraventricular hemorrhage (IVH). Due to the correlation between hypotension and fluctuation of blood pressure, treatment was targeted specifically at hypotension to prevent IVH, but this was not successful. Recently, several novel perfusion markers have been found to be correlated with the development of IVH, and they are of current interest in cardiovascular management. In this review, the correlation between IVH and conventional, as well as novel, perfusion markers is examined.
