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Epigenetic silencing of protocadherin 10 in colorectal cancer

Xian Zhong1,2, Hong Shen1, Jianshan Mao3

  • 1Department of Medical Oncology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China.

Oncology Letters
|April 30, 2017
PubMed

Insights

Epigenetic silencing of protocadherin 10 (PCDH10) is crucial in colorectal cancer development. Aberrant PCDH10 methylation may serve as an early, non-invasive biomarker for colorectal cancer screening.

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Colorectal cancer (CRC) arises from accumulated genetic and epigenetic alterations.
  • Tumor suppressor gene (TSG) inactivation via promoter methylation is a key mechanism in CRC pathogenesis.
  • Aberrant DNA methylation is a recognized hallmark of CRC.

Purpose of the Study:

  • To review the role of epigenetic alterations in protocadherin 10 (PCDH10) during colorectal cancer development.
  • To evaluate the potential of PCDH10 as a non-invasive biomarker for CRC.

Main Methods:

  • Literature review focusing on epigenetic modifications in CRC.
  • Analysis of studies investigating PCDH10 methylation in colorectal carcinogenesis.
  • Examination of research on non-invasive biomarker detection methods.

Main Results:

  • Epigenetic silencing of PCDH10, a tumor suppressor gene, is a frequent and early event in colorectal carcinogenesis.
  • PCDH10 inactivation plays a significant role in CRC invasion and metastasis.
  • Advances in methylation detection offer potential for non-invasive CRC screening.

Conclusions:

  • PCDH10 epigenetic alterations are integral to CRC development.
  • PCDH10 methylation status holds promise as a non-invasive biomarker for early CRC detection and screening.
Keywords:
DNA methylationcolorectal cancerprotocadherin 10tumor biomarkertumor suppressor gene

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