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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Related Experiment Video

Updated: Mar 3, 2026

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules
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Layer-by-Layer polyelectrolyte assemblies for encapsulation and release of active compounds.

Eduardo Guzmán1, Ana Mateos-Maroto1, Marta Ruano2

  • 1Departamento de Química Física I, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain.

Advances in Colloid and Interface Science
|April 30, 2017
PubMed
Summary
This summary is machine-generated.

The Layer-by-Layer (LbL) approach enables versatile fabrication of soft assemblies for advanced biomaterials and drug delivery. This method precisely controls material properties for effective encapsulation and release of active compounds.

Keywords:
Active compoundsCargo systemsDrug deliveryLayer-by-LayerMultilayersPolyelectrolytesSelf-assembly

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Layer-by-Layer (LbL) assembly is a versatile technique for creating soft materials.
  • LbL allows fabrication of supramolecular multifunctional materials using diverse building blocks and interactions.
  • These materials offer precise control over size, shape, composition, and morphology at the nanoscale.

Purpose of the Study:

  • To review the physico-chemical aspects of LbL assembly for supramolecular materials.
  • To highlight the role of these aspects in the application of LbL materials as cargo platforms.
  • To discuss the encapsulation and release of active compounds using LbL-assembled systems.

Main Methods:

  • Review of literature on Layer-by-Layer (LbL) assembly.
  • Analysis of physico-chemical properties governing LbL material formation.
  • Examination of LbL applications in drug delivery and biomaterials.

Main Results:

  • LbL assembly provides extraordinary versatility in material design.
  • Precise control over nanometer-scale properties is achievable.
  • LbL-assembled materials show significant potential as cargo systems for active compounds.

Conclusions:

  • The LbL approach is a powerful tool for developing advanced biomaterials and drug delivery platforms.
  • Understanding physico-chemical aspects is crucial for optimizing LbL materials for cargo applications.
  • LbL-assembled soft assemblies offer promising perspectives for encapsulation and controlled release.