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Updated: Mar 3, 2026

Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions
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Drug Blocks Synaptic Hijacking in Gliomas

    Cancer Discovery
    |April 30, 2017
    PubMed

    Insights

    Researchers discovered that blocking the ADAM10 enzyme inhibits the growth of pediatric brain tumors like glioblastoma. This finding offers a potential new therapeutic strategy for aggressive brain cancers.

    Area of Science:

    • Neuroscience
    • Oncology
    • Enzymology

    Background:

    • ADAM10 enzyme cleaves synaptic membrane proteins.
    • This cleavage produces a soluble factor that promotes brain tumor growth.

    Purpose of the Study:

    • To investigate the role of ADAM10 in pediatric brain tumor progression.
    • To evaluate the efficacy of blocking ADAM10 as a therapeutic strategy.

    Main Methods:

    • Utilized xenograft models for pediatric glioblastoma and diffuse intrinsic pontine glioma.
    • Administered treatments to block ADAM10 activity.

    Main Results:

    • Blocking ADAM10 significantly reduced tumor size in xenograft models.
    • Demonstrated the enzyme's critical role in fueling tumor growth.

    Conclusions:

    • Targeting ADAM10 presents a promising therapeutic avenue for pediatric brain cancers.
    • Further research into ADAM10 inhibitors is warranted for glioblastoma and DIPG.

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