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Updated: Mar 3, 2026

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
New ellagitannins from Tiencha and their inhibitory activity against dental plaque
Fusako Nakano1, Shozo Miyoshi2, Toshiyuki Murakami2
1Maruzen Pharmaceuticals Co.Ltd., 1089-8 Sagata, Shin-ichi, Fukuyama, Hiroshima, 729-3102, Japan. f-nakano@maruzenpcy.co.jp.
Abstract:
Four new galloyl-oxygen-diphenyl (GOD)-type ellagitannins, brambliins A-D (1-4), were isolated from the leaves of Rubus suavissimus. Their structures were elucidated by extensive spectroscopic analyses and the absolute configurations of 1-4 were determined by chemical and phytochemical evidence. These GOD-type ellagitannins inhibited the formation of dental plaque, which is beneficial for oral hygiene.
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