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Treatment of Pediatric Chronic Kidney Disease-Mineral and Bone Disorder

Mark R Hanudel1,2, Isidro B Salusky3

  • 1Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. mhanudel@mednet.ucla.edu.

Current Osteoporosis Reports
|April 30, 2017
PubMed

Insights

Chronic kidney disease-mineral and bone disorder (CKD-MBD) in children can cause skeletal problems and cardiovascular issues. Early management of fibroblast growth factor 23 (FGF23) and mineral imbalances is crucial for pediatric CKD patients.

Area of Science:

  • Nephrology
  • Pediatric Endocrinology
  • Skeletal Biology

Background:

  • Chronic kidney disease-mineral and bone disorder (CKD-MBD) significantly impacts pediatric patients, leading to fractures, growth impairment, and skeletal deformities.
  • Extra-skeletal calcification and cardiovascular complications are serious consequences of CKD-MBD in children.
  • Elevated fibroblast growth factor 23 (FGF23) levels are recognized as a primary driver in the pathogenesis of CKD-MBD.

Purpose of the Study:

  • To review the pathogenesis and current treatment strategies for CKD-MBD in pediatric populations.
  • To highlight the importance of addressing mineral and bone metabolism disorders in children with CKD.
  • To discuss the role of FGF23 in CKD-MBD and emerging therapeutic targets.

Main Methods:

  • Literature review of pathogenesis and treatment of CKD-MBD.
  • Focus on pediatric CKD patient populations.
  • Analysis of the role of FGF23 and mineral imbalances.

Main Results:

  • CKD-MBD in children leads to significant skeletal and cardiovascular complications.
  • Early elevation of FGF23 is a key factor in disease development.
  • Current treatments focus on managing hyperphosphatemia and secondary hyperparathyroidism.

Conclusions:

  • CKD-MBD is a systemic disorder requiring specialized pediatric care.
  • Optimizing skeletal health, growth, and preventing cardiovascular disease are primary treatment goals.
  • Further research into FGF23 reduction therapies is ongoing and promising.
Abstract

Keywords:
CKD-mineral and bone disorderChildrenChronic kidney diseasePathogenesisTreatment of CKD-MBD

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