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Sleep disturbance in mild cognitive impairment: a systematic review of objective measures

Mingyue Hu1, Ping Zhang1, Chen Li1

  • 1College of Nursing, Jilin University, 965 Xinjiang Road, Changchun, 130021, China.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|April 30, 2017
PubMed

Insights

Patients with mild cognitive impairment (MCI) experience significant sleep disturbances, including reduced sleep efficiency and increased sleep latency. Different subtypes of MCI show distinct sleep pattern alterations, suggesting sleep disruption is integral to cognitive decline.

Area of Science:

  • Neuroscience
  • Sleep Medicine
  • Gerontology

Background:

  • Sleep disturbance is common in mild cognitive impairment (MCI) and may contribute to cognitive decline.
  • Objective measures are needed to understand sleep alterations in MCI.

Purpose of the Study:

  • To systematically review and meta-analyze objective sleep parameters in MCI patients compared to healthy elders (HE).
  • To identify specific sleep alterations associated with different MCI subtypes.

Main Methods:

  • Systematic literature search of multiple databases up to January 2016.
  • Meta-analysis of ten case-control studies (225 MCI patients, 235 HE) using polysomnography and actigraphy.

Main Results:

  • MCI patients exhibited increased sleep latency (SL) and reduced sleep efficiency (SE) compared to HE.
  • MCI patients showed reduced total sleep time (TST) and SE, and increased SL and cyclic alternating pattern (CAP).
  • Amnestic MCI (aMCI) patients had less arousal index (AI), while non-amnestic MCI (naMCI) patients had more TST and less AI. naMCI patients had higher AI than aMCI patients.

Conclusions:

  • MCI patients generally experience more severe sleep disturbances.
  • Distinct sleep disturbance patterns are observed in different subtypes of MCI, highlighting the complexity of sleep's role in cognitive impairment.
Keywords:
ActigraphyMeta-analysisMild cognitive impairmentPSGSleep disturbance

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