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Updated: Mar 3, 2026

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
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A Proposed Peritoneal-Based Wearable Artificial Kidney.

M Roberts1, D B N Lee1

  • 1Greater Los Angeles Healthcare System, Sepulveda, California, U.S.A.

Home Hemodialysis International. International Symposium on Home Hemodialysis
|April 30, 2017
PubMed
Summary

A novel wearable artificial kidney using peritoneal dialysis offers improved toxin removal and patient freedom. This continuous system regenerates dialysate, addressing limitations of current dialysis methods.

Keywords:
REDY Sorbent SystemWearable artificial kidneyperitoneal dialysis

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Area of Science:

  • Biomedical Engineering
  • Nephrology
  • Medical Devices

Background:

  • Current dialysis methods like continuous ambulatory peritoneal dialysis (CAPD) offer patient freedom but provide inadequate dialysis and fail to remove protein-bound toxins.
  • An ideal artificial kidney should mimic natural kidney functions: continuous metabolic control, efficient toxin removal, and patient mobility.

Purpose of the Study:

  • To propose a continuous, wearable, peritoneal-based artificial kidney system.
  • To enhance dialysis efficiency and toxin clearance while minimizing protein loss.

Main Methods:

  • Regeneration of spent peritoneal dialysate using a miniaturized REDY sorbent cartridge.
  • Chemically binding urease to an inert support to prevent displacement by protein.
  • Utilizing a dual lumen catheter for continuous dialysate flow through the peritoneal cavity.
  • Implementing a dialysate flow rate of 4 L/hour through the peritoneal cavity, with 2 L/hour passing through the sorbent cartridge.

Main Results:

  • Estimated weekly Kt/V of 6.5 and creatinine clearance of 250 L.
  • Effective stripping of toxins from protein in spent dialysate, minimizing protein loss.
  • Reduced disposable components, with only the sorbent cartridge and infusate requiring changes every 8 hours.

Conclusions:

  • The proposed wearable artificial kidney offers a significant advancement over existing CAPD systems.
  • This innovative design promises improved metabolic control, enhanced toxin removal, and greater patient freedom.
  • Further development could lead to a more effective and convenient artificial kidney solution.