Plasma chemerin in young untrained men: association with cardio-metabolic traits and physical performance, and
Nejmeddine Ouerghi1, Mohamed Kacem Ben Fradj2, Marwa Khammassi1
1Research unit, Sportive Performance and Physical Rehabilitation, High Institute of Sports and Physical Education, Kef, University of Jendouba, Tunisia.
Insights
Plasma chemerin is linked to poor cardiometabolic health and physical performance in young men. High-intensity interval training (HIIT) improved health and performance but did not alter chemerin levels.
Area of Science:
- Endocrinology
- Exercise Physiology
- Metabolic Health
Background:
- Chemerin, an adipokine from adipose tissue, is implicated in reducing insulin sensitivity and elevating cardiometabolic risk.
- Understanding chemerin's role in metabolic health and physical fitness is crucial for developing targeted interventions.
Purpose of the Study:
- To investigate the association between plasma chemerin levels and cardiometabolic risk factors.
- To examine the relationship between chemerin and physical performance metrics.
- To determine the effect of a high-intensity interval training (HIIT) program on plasma chemerin levels.
Main Methods:
- Eighteen young men participated in an 8-week HIIT program.
- Plasma chemerin, cardiometabolic markers, and physical performance were measured pre- and post-training.
- Insulin resistance was estimated using the homeostasis model assessment (HOMA-IR).
Main Results:
- Basal plasma chemerin positively correlated with BMI, body fat, cholesterol, triglycerides, HOMA-IR, and C-reactive protein.
- Chemerin negatively correlated with maximal oxygen uptake and squat jump performance, but positively with sprint times.
- HIIT improved body composition, lipids, and insulin sensitivity, yet plasma chemerin levels remained unchanged.
Conclusions:
- Plasma chemerin is a significant indicator of cardiometabolic health and physical performance in young men.
- While HIIT enhances cardiometabolic health and physical fitness, it does not appear to modify circulating chemerin concentrations.
Objectives:
Chemerin is an adipose tissue-derived adipokine thought to decrease insulin sensitivity and increase cardiometabolic risk. This study aimed to assess the association of chemerin with cardiometabolic risk and physical performance and examine its response to high-intensity interval training (HIIT).
Methods:
Eighteen young men have been applied a HIIT program during 8 weeks. Plasma chemerin together with several cardiometabolic factors and physical performance indices were determined before and after the training program. Plasma chemerin and insulin were assessed using immunoenzymatic methods. The homeostasis model assessment (HOMA-IR) index was calculated as an estimate of insulin resistance.
Results:
Basal plasma chemerin was positively correlated with body mass index (r=0.782, p<0.001), body fat (r=0.767, p<0.001), total (r=0.686, p=0.002) and LDL (r=0.587, p=0.010) cholesterol, triglycerides (r=0.775, p<0.001), HOMA-IR (r=0.673, p=0.002) and C-reactive protein (r=0.765, p<0.001). With regards to physical performance, chemerin was negatively correlated with maximal oxygen uptake (r=-0.572, p=0.013) and squat jump (r=-0.627, p=0.005), but positively related to 10-m sprint (r=0.716, p=0.001) and 30-m sprint (r=0.667, p=0.002) times. HIIT program resulted in significant improvements in body composition, plasma lipids and insulin sensitivity. However, no significant change was detected for plasma chemerin in response to HIIT (134±50.7 ng/mL vs. 137±51.9 ng/mL, p=0.750).
Conclusions:
Basal plasma chemerin is associated with cardiometabolic health and physical performance in young men. Following HIIT, cardiometabolic health and physical performance had improved, but no significant change had occurred for plasma chemerin.
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