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Prevalence of multidrug-resistant gram-negative bacteria among nursing home residents: A systematic review and

Sainfer Aliyu1, Arlene Smaldone1, Elaine Larson2

  • 1Columbia University School of Nursing, New York, NY.

American Journal of Infection Control
|May 1, 2017
PubMed
Abstract

Insights

Multidrug-resistant gram-negative bacteria (MDR-GNB) are highly prevalent in nursing home residents. Enhanced infection control and prevention (ICP) policies are crucial to address this growing public health concern.

Area of Science:

  • Microbiology
  • Public Health
  • Epidemiology

Background:

  • Multidrug-resistant gram-negative bacteria (MDR-GNB) infections are increasing among nursing home (NH) residents.
  • MDR-GNB poses a significant threat to this vulnerable population.
  • Understanding the prevalence of MDR-GNB is critical for effective control.

Purpose of the Study:

  • To systematically review and meta-analyze the prevalence of MDR-GNB colonization in NH residents.
  • To critically evaluate existing evidence on MDR-GNB in this setting.

Main Methods:

  • Systematic literature review (2005-2016) following MOOSE guidelines.
  • Quality appraisal using Downs and Black criteria.
  • Random effects meta-analysis of prevalence data from 2,720 NH residents.

Main Results:

  • Eight studies met meta-analysis criteria; Escherichia coli was the most common isolate.
  • MDR-GNB colonization prevalence ranged from 11.2% to 59.1%.
  • Pooled prevalence of MDR-GNB colonization was 27% (95% CI, 15.2%-44.1%) with significant heterogeneity.

Conclusions:

  • High prevalence of MDR-GNB colonization necessitates improved infection control and prevention (ICP) strategies in NHs.
  • Findings underscore the urgent need for enhanced ICP policies to mitigate MDR-GNB spread.
Keywords:
Long-term care

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