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Multiplexed Point-of-Care Testing - xPOCT.

Can Dincer1, Richard Bruch2, André Kling3

  • 1University of Freiburg, Department of Microsystems Engineering (IMTEK), Laboratory for Sensors, Georges-Koehler-Allee 103, 79110 Freiburg, Germany; University of Freiburg, Freiburg Materials Research Center (FMF), Stefan-Meier-Straße 21, 79104 Freiburg, Germany.

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Summary

Multiplexed point-of-care testing (xPOCT) enables simultaneous detection of multiple analytes on-site. This review covers current xPOCT systems, challenges, and future applications, especially for resource-limited settings.

Keywords:
lab-on-a-chip (LOC)microfluidicsmultianalyte analysismultiplexingon-site testingpoint-of-care testing (POCT)

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Area of Science:

  • Clinical Diagnostics
  • Biomedical Engineering
  • Analytical Chemistry

Background:

  • Multiplexed point-of-care testing (xPOCT) is crucial for simultaneous on-site detection of multiple analytes from a single specimen.
  • xPOCT has growing importance in clinical diagnostics, particularly in resource-limited settings like developing countries, doctor's offices, and home use.
  • Current reviews often overlook xPOCT, focusing primarily on single-analyte approaches.

Purpose of the Study:

  • To comprehensively review current diagnostic systems and techniques for multiplexed point-of-care testing (xPOCT).
  • To discuss various multiplexing technologies and detection methods applicable to xPOCT.
  • To address unmet needs, challenges, in-field applicability, and future perspectives of xPOCT.

Main Methods:

  • Review of existing literature on multiplexed point-of-care testing systems.
  • Analysis of different multiplexing technologies, including bead-based and array-based systems.
  • Evaluation of detection methods such as electrochemical and optical techniques.

Main Results:

  • Identified and categorized various xPOCT systems and technologies.
  • Highlighted the diversity of multiplexing approaches (e.g., bead-based, array-based) and detection methods (e.g., electrochemical, optical).
  • Outlined current challenges and unmet needs in the field of xPOCT.

Conclusions:

  • xPOCT offers significant advantages for clinical diagnostics, especially in accessible healthcare settings.
  • Further development is needed to overcome existing challenges and enhance in-field applicability.
  • Future perspectives indicate a promising role for xPOCT in revolutionizing diagnostics.