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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

6.7K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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Hypoxia01:23

Hypoxia

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Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
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Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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The interplay between the cellular hypoxic response and Notch signaling.

Sebastian K-J Landor1, Urban Lendahl1

  • 1Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden; Department of Cell Biology, Åbo Akademi University, FI-20520 Turku, Finland.

Experimental Cell Research
|May 1, 2017
PubMed
Summary

Cells adapt to low oxygen via the cellular hypoxic response, involving hypoxia-inducible factors (HIFs). This process intersects with Notch signaling, crucial for stem cell regulation and differentiation, impacting various physiological and disease states.

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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Physiology

Background:

  • Cellular adaptation to low oxygen (hypoxia) is critical for survival.
  • Hypoxia-inducible factors (HIFs) are master regulators of the cellular hypoxic response.
  • Notch signaling is a key pathway controlling stem cell maintenance and differentiation.

Purpose of the Study:

  • To review the discovery and molecular mechanisms of the intersection between Notch signaling and the cellular hypoxic response.
  • To explore the physiological and disease contexts where this cross-talk is relevant.

Main Methods:

  • Literature review of studies investigating Notch and hypoxia signaling.
  • Analysis of molecular mechanisms underlying the cross-talk between these pathways.
  • Synthesis of examples from various physiological and disease contexts.

Main Results:

  • The cellular hypoxic response, mediated by HIFs, is not isolated and intersects with Notch signaling.
  • Detailed understanding of the molecular basis for the cross-talk between Notch and hypoxia is emerging.
  • This intersection plays a role in diverse physiological processes and diseases.

Conclusions:

  • The interplay between Notch signaling and the cellular hypoxic response is a significant area of biological regulation.
  • Understanding this cross-talk provides insights into stem cell biology and various pathologies.
  • Further research into this intersection holds potential for therapeutic strategies.