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Atrial natriuretic peptide and brain natriuretic peptide changes after epicardial percutaneous left atrial appendage
Insights
Percutaneous left atrial appendage closure using the LARIAT device did not alter neurohormonal markers. Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) levels remained unchanged 3 months post-procedure in non-valvular atrial fibrillation patients.
Area of Science:
- Cardiology
- Interventional Cardiology
- Biomedical Engineering
Background:
- Non-valvular atrial fibrillation (AF) poses a risk of stroke and thromboembolism.
- Percutaneous left atrial appendage (LAA) closure is an alternative treatment for risk reduction.
- The neurohormonal effects of LAA exclusion via epicardial ligation (LARIAT procedure) are not well understood.
Purpose of the Study:
- To evaluate the impact of percutaneous LAA suture ligation on atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) levels.
Main Methods:
- Sixty-six patients with non-valvular AF underwent successful percutaneous LAA closure using the LARIAT device.
- ANP and BNP levels were measured before and 3 months after the LARIAT procedure.
Main Results:
- Mean ANP levels before the procedure were 249 ± 77 pg/mL, and 3 months post-procedure were 249 ± 79 pg/mL.
- Mean BNP levels before the procedure were 481 ± 517 pg/mL, and 3 months post-procedure were 495 ± 526 pg/mL.
- No significant changes in ANP or BNP levels were observed at 3-month follow-up.
Conclusions:
- Percutaneous LAA suture ligation with the LARIAT device does not significantly alter ANP and BNP levels in patients with non-valvular AF.
- These findings suggest that LAA exclusion via this method may not have a substantial short-term neurohormonal impact.
Abstract:
Percutaneous left atrial appendage closure is an alternative treatment for stroke and systemic thromboembolism risk reduction in non-valvular atrial fibrillation (AF). However, the neurohormonal impact of epicardial exclusion of the left atrial appendage (LAA) with the LARIAT procedure is unknown. Evaluation of changes in atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) levels in AF patients underwent percutaneous LAA suture ligation. Sixty six patients underwent successfully percutaneous LAA suture ligation using LARIAT device. The level of ANP and BNP was measured before and 3 months after procedure. Mean ANP level before procedure was 249 ± 77 pg/mL (range from 95 pg/mL to 503 pg/mL) and mean BNP level was 481 ± 517 pg/mL (range from 34 pg/mL to 2508 pg/mL). Three months after procedure mean ANP level was 249 ± 79 pg/mL (range from 98 pg/mL to 492 pg/mL) and mean BNP level was 495 ± 526 pg/mL (range from 52 pg/mL to 2420 pg/mL). At 3 months follow up after percutaneous LAA suture ligation there were no significant differences in ANP and BNP levels.
