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Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH

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Hepatic segmental atrophy and nodular elastosis: imaging features.

Ishan Garg¹, Rondell P Graham², Wendaline M VanBuren¹

¹Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, 55905, USA.

Abdominal Radiology (New York)

|May 1, 2017

Summary

This summary is machine-generated.

Hepatic segmental atrophy and nodular elastosis (HSA and NE) are uncommon benign liver lesions. Imaging features can mimic metastases, but lack of FDG uptake on PET/CT may suggest a benign nature.

Keywords:

CT Hepatic segmental atrophy MRI Nodular elastosis PET Ultrasound

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Area of Science:

Radiology
Hepatology
Oncology

Background:

Hepatic segmental atrophy and nodular elastosis (HSA and NE) are rare benign liver conditions.
These lesions can present imaging characteristics that mimic malignant neoplasms, particularly liver metastases.

Purpose of the Study:

To evaluate and characterize the imaging features of hepatic segmental atrophy and nodular elastosis.
To differentiate HSA and NE from malignant liver lesions based on imaging findings.

Main Methods:

Retrospective review of imaging studies including ultrasound, CT, MRI, and PET in six patients with histologically confirmed HSA and NE.
Evaluation of lesion location, size, attenuation, signal intensity, and enhancement patterns.
Correlation of imaging findings with clinical presentation and coexistent conditions.

Main Results:

All six patients were female, with a mean age of 58.3 years. Lesions were typically small (mean 18 mm) and often detected incidentally.
CT showed hypodense lesions in most cases. MRI revealed characteristic signal intensities on T2, T1, and DWI sequences.
PET/CT demonstrated isometabolism, and Gd-EOB-DTPA-enhanced MRI showed hypointensity in the hepatobiliary phase, suggesting benignity.

Conclusions:

Hepatic segmental atrophy and nodular elastosis exhibits variable imaging features that can simulate metastases.
Lack of FDG uptake on PET/CT is a key indicator for the benign nature of HSA and NE, aiding in differential diagnosis.