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Association between Fatty Liver Disease and Hyperplastic Colonic Polyp.
Mahmud Mahamid1,2, Tarik Yassin3, Omar Abu Elheja1
1Department of Internal Medicine, Holy Family Hospital, Nazareth, Israel.
The Israel Medical Association Journal : IMAJ
|May 1, 2017
Summary
Non-alcoholic steatohepatitis (NASH) is linked to a higher incidence of hyperplastic polyps (HPs) in the colon. This study found that patients with biopsy-proven NASH had a significantly increased risk of developing HPs.
Area of Science:
- Gastroenterology
- Hepatology
- Pathology
Background:
- Hyperplastic polyps (HPs) are the most common type of colorectal polyp.
- Metabolic syndrome, including obesity and hyperlipidemia, is implicated in HP development and fatty liver disease pathogenesis.
Purpose of the Study:
- To investigate the association between biopsy-proven steatohepatitis and hyperplastic colonic polyps.
Main Methods:
- Retrospective cohort observational study at Holy Family Hospital, Nazareth, Israel.
- Included 223 patients undergoing screening colonoscopy over two years.
- Data extracted included demographics, medical history, laboratory results, and liver biopsy findings.
Main Results:
- 123 patients had non-alcoholic steatohepatitis (NASH), and 100 served as controls.
- Hyperplastic polyps were found in 22.7% of NASH patients versus 8% of controls (P < 0.05).
- Multivariate analysis revealed NASH is associated with an increased risk for HPs (OR 1.69, P < 0.01).
Conclusions:
- A significant association exists between biopsy-proven steatohepatitis and an increased burden of hyperplastic polyps.
- This finding suggests a potential link between liver health and colorectal polyp development.
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