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Published on: September 7, 2022
Lymphocyte Subset Reference Ranges in Healthy Israeli Adults
Yael Shahal-Zimra1, Zohar Rotem1, Judith Chezar
1Hematology Laboratory, Felsenstein Medical Research Center, Rabin Medical Center (Beilinson Hospital), Petah Tikva, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Background:
Reference ranges for adult peripheral blood lymphocyte subsets have been established in a few countries. To the best of our knowledge no broad lymphocyte subset analysis of the Israeli population has been reported. Objectives: To establish reference ranges for healthy adults in Israel and to describe age- and gender-specific differences, if present.
Objectives:
To establish reference ranges for healthy adults in Israel and to describe age- and gender-specific differences, if present.
Methods:
Lymphocyte subsets CD3, CD3/CD4, CD3/CD8, CD3-/CD16+/CD56+, CD3/TCRαβ, CD3/TCRγδ, and CD19 were examined by flow cytometry in 326 subjects. Samples were subdivided according to age and gender.
Results:
Women of all ages had a significantly higher percentage and absolute counts of CD3/CD4 cells than their male counterparts. Higher CD3/CD4 cells were observed also in the older population (> 50 years). CD3/CD8 and CD3-/CD16+/CD56+ were higher in males. Older males had a lower total lymphocyte percentage and CD19 cells compared to younger men. No significant gender-related differences were observed in percent and number of CD19, CD3/TCRαβ or CD3/TCRγδ at all ages.
Conclusions:
These reference values could be useful in further studies for assessing changes that occur in different populations in human pathology.
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