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Published on: September 16, 2025
Repeatability, reproducibility, agreement characteristics of 2 SD-OCT devices for anterior chamber angle measurements
Handan Akil1, Anna Dastiridou1, Kenneth Marion1
1Doheny Eye Institute, Doheny Image Reading Center, Los Angeles, California.
Objective:
To evaluate the agreement, reproducibility, and repeatability of 2 spectral domain optical coherence tomography (SD-OCT) devices in Schwalbe's line (SL)-based anterior chamber angle parameters.
Methods:
The inferior anterior chamber angle of 65 eyes from 65 participants (33 right eyes and 32 left eyes) were scanned twice with the Nidek RS 3000 Advanced SD-OCT and Cirrus SD-OCT. SL angle opening distance (SL-AOD) and SL trabecular-iris-space area (SL-TISA) were graded by masked certified graders at the Doheny Image Reading Center.
Results:
The mean SL-AOD/SL-TISA was 617.3 ± 237.9 µm/0.211 ± 0.086 mm2 for the Cirrus and 633.7 ± 219.3 µm/0.218 ± 0.080 mm2 for the Nidek RS 3000 Advanced SD-OCT. The repeatability (intraclass correlation coefficients [ICCs] >0.936) and intergrader reproducibility (ICCs >0.915) in SL-AOD and SL-TISA with Cirrus OCT were excellent. The repeatability (ICCs >0.948) and intergrader reproducibility (ICCs >0.709) in SL-AOD and SL-TISA with the Nidek RS 3000 Advanced SD-OCT were moderate to good. Moderate agreement between the 2 devices was also documented with a mean difference of -15.3 (limits of agreement [LoA] -246.5 to 277.1) mm for SL-AOD and 0.006 (LoA -0.096 to 0.108) mm in SL-TISA.
Conclusion:
Both devices were able to provide consistent angle measurements, but repeatability and reproducibility were better in Cirrus SD-OCT than in Nidek RS 3000 Advanced SD-OCT.
