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Cell-assisted lipotransfer: Current concepts.

J Laloze1, A Varin2, N Bertheuil3

  • 1Department of Plastic, Reconstructive and Aesthetic Surgery, Rangueil Hospital, 1, avenue Jean-Poulhès, 31059 Toulouse, France; STROMAlab, Université de Toulouse, EFS, ENVT, INSERM U1031, Toulouse, France.

Annales De Chirurgie Plastique Et Esthetique
|May 2, 2017
PubMed
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This summary is machine-generated.

Cell-assisted lipotransfer (CAL) enhances fat graft survival by enriching fat with adipose-derived stromal cells (ASC). This review explores CAL

Area of Science:

  • Regenerative Medicine
  • Plastic Surgery
  • Tissue Engineering

Background:

  • Autologous fat transfer (lipofilling) is widely used for soft tissue reconstruction.
  • A major limitation is significant graft resorption, ranging from 20% to 80%.
  • Cell-assisted lipotransfer (CAL) has emerged as a promising technique to improve fat graft survival.

Purpose of the Study:

  • To review the clinical indications and technical principles of cell-assisted lipotransfer (CAL).
  • To provide an overview of adipose-derived stromal cells (ASC).
  • To summarize the efficacy, complications, and safety of CAL from existing studies.

Main Methods:

  • Enrichment of autologous fat grafts with adipose-derived stromal cells (ASC).
  • ASC are sourced from the stromal vascular fraction (SVF) via enzymatic digestion or cell culture.
Keywords:
Adipose-derived stromal cellsAutologous fat graftingCell-assisted lipotransferCellules stromales mésenchymateuse du tissu adipeuxConcepts actuelsConcise reviewCurrent conceptsRevue de la littératureTransfert de tissu adipeux

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  • Review of clinical studies assessing CAL techniques and outcomes.

    • Main Results:

    • CAL demonstrates potential to improve fat graft survival rates compared to traditional lipofilling.
    • Efficacy, complication profiles, and safety data from various CAL studies are presented.
    • ASC integration and vascularization are key factors in CAL success.

    Conclusions:

    • Cell-assisted lipotransfer (CAL) represents a significant advancement in improving autologous fat graft survival.
    • ASC enrichment offers a viable strategy to overcome the resorption limitations of conventional lipofilling.
    • Further research and standardization of CAL techniques are warranted to optimize clinical outcomes.