The evolution of lipidomics through space and time

Area of Science:

• Biochemistry
• Analytical Chemistry
• Bioinformatics

Background:

• Lipidomics, utilizing mass spectrometry, has evolved over 30 years.
• Recent technological advancements have accelerated its growth and importance.
• Integration of separation sciences, bioinformatics, and databases has improved lipidomic analyses.

Purpose of the Study:

• Review the evolution of lipidomics.
• Critique current lipidomic platforms.
• Identify future directions in the field.

Main Methods:

• Mass spectrometry with advanced ionization techniques.
• High mass accuracy and resolution instruments.
• Integration of separation sciences and bioinformatics strategies.
• Utilizing robust lipid databases.

Main Results:

• Unprecedented improvements in the depth, penetrance, and precision of lipidomic analyses.
• Identification of biological and mechanistic significance of lipids.
• Quantification of tens of thousands to hundreds of thousands of lipid species and their alterations.

Conclusions:

• Lipidomics has a distinguished history of discoveries in disease states.
• The field holds unparalleled potential to elucidate the roles of lipids in health and disease.
• Seamless integration of mass spectrometry, chemical, and bioinformatic strategies is key.