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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Modified-Release Drug Delivery Systems: Overview01:19

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Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

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Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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Modified-Release Drug Delivery Systems: Influencing Factors01:20

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Modified-release drug delivery systems are designed to optimize the therapeutic effect of drugs by minimizing side effects, reducing the dosage required, and controlling drug release to align with pharmacokinetic and pharmacodynamic needs. The system depends on two key factors: the drug's release from the formulation and its movement through the body to the target site. Unlike conventional dosage forms, where absorption is the limiting step, the rate of drug release is the key determinant in...
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Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices
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Protein based therapeutic delivery agents: Contemporary developments and challenges.

Liming Yin1, Carlo Yuvienco1, Jin Kim Montclare2

  • 1Department of Chemical and Biomolecular Engineering, NYU Tandon School of Engineering, Brooklyn, NY 11201, United States.

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Proteins serve as versatile biopolymers for therapeutic delivery due to their biocompatibility and low toxicity. Advances enable tailor-made protein materials for effective transport of diverse therapeutics, including genes and cells.

Keywords:
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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Protein Engineering

Background:

  • Proteins are unique biopolymers with inherent properties like bioavailability, biocompatibility, biodegradability, and low toxicity.
  • These characteristics make proteins a promising platform for delivering various therapeutic agents, including small molecules, gene therapies, protein biologics, and cells.

Purpose of the Study:

  • To review strategies utilizing proteins for therapeutic delivery.
  • To highlight advancements in protein-based delivery systems.
  • To address challenges associated with transporting small molecules, genes, proteins, and cells using protein platforms.

Main Methods:

  • Review of existing literature on protein-based therapeutic delivery.
  • Analysis of natural and engineered proteins/peptides for delivery applications.
  • Exploration of synthetic and chemical biology advancements in creating protein materials.

Main Results:

  • Proteins offer a versatile platform for delivering a wide range of therapeutics.
  • Tailor-made protein materials have been developed using advances in synthetic and chemical biology.
  • Various strategies exist to employ proteins for effective therapeutic transport.

Conclusions:

  • Proteins are highly effective biopolymers for therapeutic delivery applications.
  • Engineered proteins and peptides represent a significant advancement in drug delivery.
  • Further research into protein-based delivery systems will overcome current transport challenges.