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Is aura around citicoline fading? A systemic review
Saurabh Agarwal1, Bhoomika M Patel1
1Department of Pharmacology, Nirma University, Ahmedabad, Gujarat, India.
Indian Journal of Pharmacology
|May 2, 2017
Summary
Citicoline significantly improved functional outcomes in stroke and TBI patients. However, its benefits for neurological recovery, domestic adaptation, and cognitive function require further investigation.
Area of Science:
- Neurology
- Neuroscience
- Pharmacology
Background:
- Stroke and traumatic brain injury (TBI) represent significant global health challenges.
- Citicoline is utilized as an adjunct therapy for acute ischemic stroke (AIS) and TBI in numerous countries.
Purpose of the Study:
- To conduct a systematic review and meta-analysis on the efficacy of citicoline in managing AIS and TBI.
- To evaluate the impact of citicoline on neurological, functional, domestic adaptation, and cognitive outcomes.
Main Methods:
- Systematic review of studies from PubMed and Science Direct.
- Inclusion of 12 human trials.
- Meta-analysis of neurological, functional, domestic adaptation, and cognitive outcomes.
Main Results:
- Citicoline showed a significant improvement in functional outcomes (OR = 1.18, P = 0.01).
- No significant differences were observed between citicoline and placebo groups for neurological evaluation (OR = 1.04, P = 0.583), domestic adaptation (OR = 1.1, P = 0.209), or cognitive outcomes (OR = 0.953, P = 0.691).
Conclusions:
- Citicoline demonstrates a significant positive effect on functional recovery following stroke and TBI.
- The role of citicoline in improving neurological recovery, domestic adaptation, and cognitive function remains inconclusive and warrants further research.
