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Levodopa-responsive depression associated with corticobasal degeneration: a case report
Natsumi Tarakita1, Haruo Nishijima2, Norio Yasui-Furukori1
1Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki.
Neuropsychiatric Disease and Treatment
|May 2, 2017
Summary
Recurrent depression in a 60-year-old woman was linked to corticobasal degeneration (CBD). Levodopa treatment improved her depression and myoclonus, suggesting CBD as the cause.
Area of Science:
- Neurology
- Neurodegenerative Diseases
Background:
- A 60-year-old female with a 13-year history of depression treated with paroxetine presented with neurological and psychiatric symptoms.
- Symptoms included clumsiness, left-hand rigidity, agraphia, memory complaints, and worsening depression with suicidal ideation.
Observation:
- The patient experienced progressive neurological decline, including myoclonus and left arm pain.
- Magnetic resonance imaging (MRI) revealed diffuse cerebral atrophy and right parietal lobe atrophy.
Findings:
- The patient was diagnosed with corticobasal degeneration (CBD).
- Levodopa administration led to improvement in left arm myoclonus and depressive symptoms.
Implications:
- This case suggests that corticobasal degeneration (CBD) may induce or exacerbate recurrent depression.
- Early recognition of neurological signs in patients with treatment-resistant depression is crucial for accurate diagnosis and management.
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