Related Experiment Video

Updated: Mar 3, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

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microRNAs: Emerging players in oral cancers and inflammatory disorders

Varun Kulkarni1, Juhi Raju Uttamani1, Afsar Raza Naqvi1

  • 11 Department of Periodontics, College of Dentistry, The University of Illinois at Chicago, Chicago, IL, USA.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
|May 2, 2017
PubMed

Insights

MicroRNAs (miRNAs) show altered profiles in oral diseases, indicating their potential as diagnostic biomarkers and therapeutic targets for oral cancers and inflammatory conditions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oral Medicine

Background:

  • MicroRNAs (miRNAs) are recognized for their association with oral diseases.
  • Altered miRNA signatures are linked to oral cancers and inflammatory conditions.
  • miRNAs hold potential as diagnostic and therapeutic tools.

Purpose of the Study:

  • To review the association between altered miRNA signatures and oral diseases.
  • To highlight the clinical value of miRNAs as biomarkers.
  • To discuss the therapeutic potential of miRNAs in oral disease treatment.

Main Methods:

  • Literature review of studies on microRNAs in oral diseases.
  • Analysis of miRNA dysregulation mechanisms in pathological conditions.
  • Evaluation of current and future applications of miRNAs in oral medicine.

Main Results:

  • miRNA profiles are altered in oral cancers and inflammatory diseases.
  • Detection of miRNAs in serum and saliva supports their biomarker potential.
  • Key mechanisms of miRNA dysregulation in oral pathology have been identified.

Conclusions:

  • Altered microRNA signatures are strongly associated with oral diseases.
  • MicroRNAs show significant promise as biomarkers for diagnosis and prognosis.
  • MicroRNAs represent a potential therapeutic avenue for oral diseases.
Keywords:
MicroRNAinflammatory disordersoral canceroral pathology

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