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Published on: September 20, 2016
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Next-generation sequencing for endocrine cancers: Recent advances and challenges
Padmanaban S Suresh1, Thejaswini Venkatesh2, Rie Tsutsumi3
11 Department of Biosciences, Mangalore University, Mangalore, India.
Summary
Next-generation sequencing (NGS) advances offer powerful tools for understanding endocrine cancers. This review highlights NGS applications in clinical diagnosis and future directions for endocrine tumor genetic testing.
Area of Science:
- Biomedical Research
- Molecular Biology
- Oncology
Background:
- Endocrine cancers present significant healthcare challenges.
- Molecular biology tools like microarrays have provided insights into disease states.
- Next-generation sequencing (NGS) offers advantages over microarrays for clinical research.
Purpose of the Study:
- To review recent advances in NGS methods for endocrine and endocrine-related cancers.
- To illustrate the potential of NGS platforms in clinical genetic testing.
- To discuss challenges and future perspectives in NGS applications for endocrine tumors.
Main Methods:
- Review of recent literature on next-generation sequencing.
- Analysis of NGS applications in endocrine cancer research and clinical diagnosis.
- Discussion of technological platforms, challenges, and future objectives.
Main Results:
- NGS provides valuable data for prognosis and drug target identification in endocrine cancers.
- Recent discoveries showcase NGS's utility in the clinical diagnosis of endocrine tumors.
- NGS overcomes limitations of older technologies like microarrays.
Conclusions:
- NGS is a crucial technology for advancing the understanding and treatment of endocrine cancers.
- Further development and application of NGS are essential for personalized genetic testing in endocrine tumors.
- Addressing current challenges will optimize the future clinical utility of NGS.
