Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Pfcrt</i> copy number amplification detected in a <i>Plasmodium falciparum</i> outbreak.

bioRxiv : the preprint server for biology·2026
Same author

Chikungunya.

JAMA·2026
Same author

The Presence of Leishmania infantum DNA in Sand Flies Reflects Their Proximity to Human and Canine Visceral Leishmaniasis.

The American journal of tropical medicine and hygiene·2026
Same author

Human macrophages release exosomes containing anti-inflammatory microRNAs after phagocytosis of <i>Leishmania infantum</i>.

Frontiers in immunology·2025
Same author

Pf8: an open dataset of <i>Plasmodium falciparum </i>genome variation in 33,325 worldwide samples.

Wellcome open research·2025
Same author

Chikungunya vaccination for travellers: practical guidance for clinical decision-making.

Journal of travel medicine·2025

Related Experiment Video

Updated: Mar 3, 2026

Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult
09:39

Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult

Published on: April 26, 2018

9.2K

Postmortem Findings for 7 Neonates with Congenital Zika Virus Infection.

Anastácio Q Sousa, Diane I M Cavalcante, Luciano M Franco

    Emerging Infectious Diseases
    |May 2, 2017
    PubMed
    Summary

    Congenital Zika virus infection in neonates caused severe brain abnormalities, including microcephaly and neuronal loss. The virus also led to multiple organ damage, confirming its widespread impact.

    Keywords:
    BrazilZika virusautopsycongenitalmicrocephalyneonatespostmortemviruses

    More Related Videos

    Modelling Zika Virus Infection of the Developing Human Brain In Vitro Using Stem Cell Derived Cerebral Organoids
    09:18

    Modelling Zika Virus Infection of the Developing Human Brain In Vitro Using Stem Cell Derived Cerebral Organoids

    Published on: September 19, 2017

    11.0K
    Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1-/- Mice
    10:01

    Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1-/- Mice

    Published on: October 17, 2018

    8.5K

    Related Experiment Videos

    Last Updated: Mar 3, 2026

    Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult
    09:39

    Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult

    Published on: April 26, 2018

    9.2K
    Modelling Zika Virus Infection of the Developing Human Brain In Vitro Using Stem Cell Derived Cerebral Organoids
    09:18

    Modelling Zika Virus Infection of the Developing Human Brain In Vitro Using Stem Cell Derived Cerebral Organoids

    Published on: September 19, 2017

    11.0K
    Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1-/- Mice
    10:01

    Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1-/- Mice

    Published on: October 17, 2018

    8.5K

    Area of Science:

    • Neurology
    • Virology
    • Pediatrics

    Background:

    • Congenital Zika virus infection is a significant public health concern.
    • The full spectrum of pathological findings in affected neonates requires further elucidation.

    Purpose of the Study:

    • To detail the neuropathological and systemic findings in neonates with congenital Zika virus infection.
    • To confirm Zika virus neurotropism and multi-organ involvement.

    Main Methods:

    • Postmortem examination of 7 neonates with confirmed congenital Zika virus infection.
    • Histopathological analysis of brain, lung, and liver tissues.

    Main Results:

    • All neonates exhibited microcephaly, ventriculomegaly, dystrophic calcifications, and severe cortical neuronal depletion.
    • Arthrogryposis was observed in 6 neonates.
    • Leptomeningeal and brain parenchymal inflammation, pulmonary hypoplasia, and lymphocytic infiltration in liver and lungs were noted.

    Conclusions:

    • Congenital Zika virus infection causes severe central nervous system malformations and neuronal loss.
    • The findings confirm Zika virus's neurotropism and its capacity to infect multiple organs in neonates.
    • This study highlights the devastating impact of prenatal Zika virus exposure.