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Transamination of LTE4 by cysteine conjugate aminotransferase
H Tomisawa1, Y Takanohashi, S Ichihara
1Department of Drug Metabolism, Nippon Roche Research Center, Kanagawa Pref., Japan.
Biochemical and Biophysical Research Communications
|September 30, 1988
Abstract:
Leukotriene E4 (LTE4) was transaminated to 5(S)-hydroxy-6(R)-S-(2-keto-3-thiopropionyl)-7,9-trans-11,14-cis- eicosatetraenoic acid (tentatively designated as LTG4) by cysteine conjugate aminotransferase I purified from rat liver supernatant in the presence of alpha-ketoglutaric acid or alpha-keto-gamma-methiolbutyric acid. The transamination activity was present in the kidney as well as in the liver, but not in the lung or leukocytes.