Advanced MRI of the Optic Nerve

Area of Science:

• Radiology and Medical Imaging
• Neuroscience
• Ophthalmology

Background:

• Conventional MRI protocols face challenges in characterizing optic nerves due to their small size, oblique orientation, and signal distortion from adjacent bony structures.
• Motion artifacts further complicate imaging, even in cooperative subjects, limiting detailed analysis of optic nerve pathology.

Purpose of the Study:

• To review recent innovations in MRI sequences and techniques for improved optic nerve characterization.
• To highlight advancements translating into clinical practice for noninvasive study of optic nerve pathologies.

Main Methods:

• Exploration of novel MRI approaches and sequences over three years.
• Discussion of rapid MRI techniques like compressed sensing and simultaneous multislice imaging.
• Inclusion of postprocessing methods such as quantitative T2 mapping, track density imaging, and diffusion measurement sequences.

Main Results:

• Recent MRI sequence innovations are being translated into clinical practice for optic nerve imaging.
• Advanced techniques improve spatial resolution, acquisition speed, and motion resistance.
• Quantitative sequences and specialized coils enhance the ability to study optic nerve pathologies.

Conclusions:

• Orbit-specific MRI coils, quantitative sequences, and rapid acquisition techniques improve noninvasive study of optic nerve pathologies.
• Increased proficiency of advanced MRI in characterizing optic nerves will expand its clinical utility.
• Enhanced MRI capabilities promise a greater role in the clinical management of patients with optic nerve conditions.