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Inhibitory effects of psoralens on rat liver cyclic AMP phosphodiesterase
L Bovalini1, P Lusini, S Simoni
1Institute of Biological Chemistry, University of Siena, Italy.
Biochemistry International
|June 1, 1988
Abstract:
TMP (4,5',8-trimethylpsoralen) usually employed in PUVA therapy and TMA (4,6,4'-trimethylangelicin), phototherapeutic agent under clinical and biological investigation, show an inhibitory effect of competitive type on the low Km cyclic AMP phosphodiesterase present in rat liver. The two drugs exhibit Ki values of 135 and 320 microM, respectively.