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Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
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Follicular helper T cells in the pathogenesis of IgG4-related disease

Mitsuhiro Akiyama1, Katsuya Suzuki1, Hidekata Yasuoka1

  • 1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

Rheumatology (Oxford, England)
|May 2, 2017
PubMed

IgG4-related disease (IgG4-RD) is a recently recognized disease entity characterized by high serum IgG4 concentrations and infiltration of IgG4+ plasma cells with hyperplastic ectopic germinal centres at affected sites. Although the underlying immune mechanism of this disease remains unclear, T cells are abundantly present at affected sites and key players in IgG4-RD pathogenesis. The role of T cell subsets has been investigated thoroughly in this disease. Recent advances in this field have clarified the importance of T follicular helper cells. In this review, we describe the role of T follicular helper cells in the disease process of IgG4-RD, in particular, for IgG4 class-switching, plasmablast and plasma cell differentiation, and germinal centre formation.

Keywords:
IgG4-related diseaseT follicular helper cellT lymphocytegerminal centreinterleukin-21interleukin-4pathogenesisplasmablastsomatic hypermutation

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