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Adenylate cyclase and alpha-2-adrenoceptors in thrombocytes of chronic uremic patients
F Lübbecke1, J Sandelbaum, G Schütterle
1Center of Internal Medicine, Justus Liebig University, Giessen, FRG.
Blood Purification
|January 1, 1988
Abstract:
Thrombocyte adenylate cyclase regulation and alpha-2-adrenoceptors have been studied in uremic patients as well as in healthy controls. Stimulation of adenylate cyclase activity by PGE1 and forskolin as well as inhibition by (+/-)-epinephrine was not significantly different between both groups. Additionally, there was no evidence of an alteration of the thrombocyte alpha-2-adrenoceptor density, determined by 3H-rauwolscine binding as suggested by others.