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Process Optimization using High Throughput Automated Micro-Bioreactors in Chinese Hamster Ovary Cell Cultivation

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High-Throughput Automation in Chemical Process Development.

Joshua A Selekman¹, Jun Qiu¹, Kristy Tran¹

¹Chemical and Synthetic Development, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903; email: joshua.selekman@bms.com , jun.qiu@bms.com , kristy.tran@bms.com , jason.stevens@bms.com , victor.rosso@bms.com , eric.simmons@bms.com , yi.xiao@bms.com , jacob.janey@bms.com.

Annual Review of Chemical and Biomolecular Engineering

|May 2, 2017

Summary

This summary is machine-generated.

High-throughput (HT) technologies accelerate chemical process development using laboratory automation and statistical design. This review covers HT automation

Keywords:

design of experiments laboratory automation miniaturization parallel experimentation process optimization

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Area of Science:

Chemical Engineering
Process Development
Laboratory Automation

Background:

High-throughput (HT) techniques leverage laboratory automation for accelerated chemical process development.
These methods interrogate vast experimental spaces for optimizing chemical engineering unit operations.

Purpose of the Study:

To review the evolution of HT technology.
To provide a comprehensive overview of HT automation in various industries, focusing on chemical and pharmaceutical sectors.
To highlight strategies for integrating HT automation into routine development.

Main Methods:

Literature review of HT technology evolution.
Analysis of HT automation applications in chemical and pharmaceutical process development.
Identification of common integration strategies for routine development.

Main Results:

HT technologies have significantly accelerated chemical process development.
HT automation is widely applied across industries for process design and optimization.
Effective integration strategies maximize the impact of HT automation in academic and industrial settings.

Conclusions:

HT automation is a key enabler for efficient chemical and pharmaceutical process development.
Understanding the evolution and application of HT technologies is crucial for maximizing their benefits.
Strategic implementation of HT automation enhances routine development activities.