Related Experiment Video
Updated: Sep 13, 2026

A High-throughput Automated Platform for the Development of Manufacturing Cell Lines for Protein Therapeutics
Published on: September 22, 2011
High-Throughput Automation in Chemical Process Development
Joshua A Selekman1, Jun Qiu1, Kristy Tran1
1Chemical and Synthetic Development, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903; email: joshua.selekman@bms.com , jun.qiu@bms.com , kristy.tran@bms.com , jason.stevens@bms.com , victor.rosso@bms.com , eric.simmons@bms.com , yi.xiao@bms.com , jacob.janey@bms.com.
Abstract:
High-throughput (HT) techniques built upon laboratory automation technology and coupled to statistical experimental design and parallel experimentation have enabled the acceleration of chemical process development across multiple industries. HT technologies are often applied to interrogate wide, often multidimensional experimental spaces to inform the design and optimization of any number of unit operations that chemical engineers use in process development. In this review, we outline the evolution of HT technology and provide a comprehensive overview of how HT automation is used throughout different industries, with a particular focus on chemical and pharmaceutical process development. In addition, we highlight the common strategies of how HT automation is incorporated into routine development activities to maximize its impact in various academic and industrial settings.
More Related Videos
11:58Optimizing the Use of a Liquid Handling Robot to Conduct a High Throughput Forward Chemical Genetics Screen of Arabidopsis thaliana
Published on: April 30, 2018
09:28Process Optimization using High Throughput Automated Micro-Bioreactors in Chinese Hamster Ovary Cell Cultivation
Published on: May 18, 2020
Related Concept Videos
Scale-Up Processes
Upstream Processing
Downstream Processing