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Vitamin D Metabolism and Potential Effects of Vitamin D Receptor Modulation in Chronic Kidney Disease

Antonio Bellasi1, Andrea Galassi2, Michela Mangano2

  • 1Renal and Dialysis Division Ospedale Sant'Anna-Como, ASST-Lariana, Via Ravona, 20 - 22020 Como. Italy.

Current Drug Metabolism
|May 3, 2017
PubMed
Abstract

Insights

Vitamin D deficiency impacts Chronic Kidney Disease (CKD) and secondary hyperparathyroidism. This review explores vitamin D receptor

Area of Science:

  • Nephrology
  • Endocrinology
  • Molecular Biology

Background:

  • Vitamin D deficiency is a key factor in secondary hyperparathyroidism associated with Chronic Kidney Disease (CKD).
  • Emerging evidence suggests vitamin D has broader, pleiotropic effects beyond mineral metabolism.
  • The vitamin D receptor is present in diverse tissues, influencing multiple physiological systems.

Purpose of the Study:

  • To review vitamin D metabolism and its diverse effects.
  • To emphasize the role of vitamin D receptor modulation beyond parathyroid hormone regulation.

Main Methods:

  • Literature review of existing studies on vitamin D metabolism and function.
  • Analysis of research on vitamin D receptor's impact on various organ systems.

Main Results:

  • Vitamin D plays a crucial role in CKD and secondary hyperparathyroidism.
  • Vitamin D receptor activation impacts parathyroid, intestinal, cardiovascular, and immune functions.
  • Non-classical effects of vitamin D are significant and widespread.

Conclusions:

  • Vitamin D metabolism and its receptor's functions are critical in health and disease.
  • Modulating the vitamin D receptor offers therapeutic potential beyond managing mineral metabolism in CKD.
Keywords:
CKD-MBDVitamin D receptorparacalcitolvitamin Dvitamin D deficiency

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