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Apoptosis in ischemic heart disease
Elena Teringova1, Petr Tousek2
1Cardiocenter, Department of Cardiology, 3rd Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Srobarova 50, 100 34, Prague 10, Czech Republic.
Journal of Translational Medicine
|May 3, 2017
Summary
Apoptosis is key in heart damage after myocardial infarction. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) shows promise as a prognostic marker for acute myocardial infarction patients.
Area of Science:
- Cardiology
- Cell Biology
- Biochemistry
Background:
- Apoptosis, or programmed cell death, is a critical factor in myocardial loss following acute myocardial infarction (AMI).
- This process significantly influences left ventricular remodeling and the progression to symptomatic heart failure.
- Identifying reliable apoptotic markers is crucial for patient prognosis and therapeutic development in ischemic heart disease.
Purpose of the Study:
- To review the current understanding of apoptosis in ischemic heart disease.
- To highlight the potential of apoptotic markers, particularly TRAIL, for prognostic stratification in AMI patients.
- To explore new therapeutic strategies targeting apoptosis in heart failure.
Main Methods:
- Literature review of studies on apoptosis in myocardial infarction and heart failure.
- Analysis of research investigating the role of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as a prognostic marker.
- Synthesis of current knowledge on apoptotic pathways and their clinical implications.
Main Results:
- Apoptosis is a significant contributor to myocardial damage and adverse ventricular remodeling post-AMI.
- Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has emerged as a promising biomarker for predicting outcomes in AMI patients.
- Several apoptotic pathways are implicated in the pathophysiology of ischemic heart disease.
Conclusions:
- Apoptosis is integral to the pathogenesis of heart failure following myocardial infarction.
- TRAIL holds significant potential as a prognostic tool for stratifying AMI patient risk.
- Further research into apoptotic markers could lead to novel therapeutic interventions for heart disease.
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