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Related Experiment Videos

Core outcome sets for research and clinical practice.

Alessandro Chiarotto1, Raymond W Ostelo1, Dennis C Turk2

  • 1Department of Health Sciences, Faculty of Earth and Life Sciences, EMGO(+) Institute for Health and Care Research, Vrije Universiteit, Amsterdam, Netherlands; Department of Epidemiology and Biostatistics, EMGO(+) Institute for Health and Care Research, VU Medical Center, Amsterdam, Netherlands.

Brazilian Journal of Physical Therapy
|May 3, 2017
PubMed
Summary

Core outcome sets (COSs) standardize outcome measurement in clinical trials. Developing COSs requires consensus on outcome domains and instruments, involving diverse stakeholders like patients.

Keywords:
Core outcome setEffectivenessInterventionsMusculoskeletal pain

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Area of Science:

  • Clinical Research Methodology
  • Health Outcomes Research

Background:

  • Core outcome sets (COSs) aim to standardize outcome measurement in clinical trials.
  • They address issues like selective reporting and inconsistency across studies.

Purpose of the Study:

  • To introduce the concept, rationale, and methods for developing core outcome sets.
  • To provide examples of existing COSs and identify areas for future development.

Main Methods:

  • Development involves achieving consensus on core outcome domains and measurement instruments.
  • Methods include systematic reviews, qualitative research, group discussions, and Delphi techniques.
  • Involvement of diverse stakeholders, especially patients, is crucial.

Main Results:

  • Existing COSs are prevalent in musculoskeletal conditions (e.g., low back pain, osteoarthritis).
  • There's a notable absence of COSs for neurological, geriatric, cardio-respiratory, and pediatric conditions.

Conclusions:

  • COSs are valuable for improving the quality and comparability of clinical trial data.
  • Future research should focus on developing COSs for underrepresented medical fields.