Subclinical ventricular repolarization abnormality in uncontrolled compared with controlled treated hypertension
Marwan S M Al-Nimer1, Ismail I Hussein2
1Department of Pharmacology, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq.
Indian Heart Journal
|May 3, 2017
Summary
Hypertension patients may have ventricular repolarization issues, increasing cardiac arrhythmia risk, regardless of blood pressure control. This study highlights subclinical conduction defects in hypertensive individuals.
Area of Science:
- Cardiology
- Pharmacology
- Physiology
Background:
- Antihypertensive medications impact QT interval duration.
- Hypertension management requires understanding subclinical ventricular conduction defects.
- Blood pressure control status influences treatment outcomes.
Purpose of the Study:
- To investigate subclinical ventricular conduction defects in hypertensive patients.
- To assess the relationship between blood pressure control and ventricular repolarization.
- To identify patients at risk for cardiac arrhythmias.
Main Methods:
- Cross-sectional study involving 97 hypertensive patients.
- Patients categorized into controlled (Group I) and uncontrolled (Group II) hypertension.
- Electrocardiograph (ECG) and QT nomogram plots used for risk assessment.
Main Results:
- No significant ECG determinant differences between controlled and uncontrolled hypertension groups.
- Abnormal prolonged QTcB interval in 22.5% of uncontrolled hypertensive patients.
- Significant correlation between QTcB duration and JT index in both groups.
Conclusions:
- Hypertension is associated with variable ventricular repolarization (QTcB and JT indices).
- These repolarization changes occur irrespective of blood pressure control.
- Patients with hypertension face an elevated risk of cardiac arrhythmias.
More Related Videos
Related Concept Videos
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
686
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
686
01:25ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias
716
Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
716
01:29Hypertension II: Pathophysiology
1.2K
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.2K
01:29Disturbances in Heart Rhythm
3.4K
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
3.4K
01:18Hypertension and Regulation of Blood Pressure
4.6K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
4.6K
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
1.3K
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
1.3K