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Updated: Mar 3, 2026

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Published on: December 22, 2016
Forced Normalization: Antagonism Between Epilepsy and Psychosis
Yasuhiko Kawakami1, Yasuhiko Itoh2
1Department of Pediatrics, Nippon Medical School, Bunkyo-ku, Tokyo, Japan; Department of Pediatrics, Nippon Medical School Tama Nagayama Hospital, Tama-shi, Tokyo, Japan.
Abstract:
The antagonism between epilepsy and psychosis has been discussed for a long time. Landolt coined the term "forced normalization" in the 1950s to describe psychotic episodes associated with the remission of seizures and disappearance of epileptiform activity on electroencephalograms in individuals with epilepsy. Since then, neurologists and psychiatrists have been intrigued by this phenomenon. However, although collaborative clinical studies and basic experimental researches have been performed, the mechanism of forced normalization remains unknown. In this review article, we present a historical overview of the concept of forced normalization, and discuss potential pathogenic mechanisms and clinical diagnosis. We also discuss the role of dopamine, which appears to be a key factor in the mechanism of forced normalization.
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