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The responsiveness of mice B-lymphocytes to neuromediators during an immune reaction

A D Ado1, M M Goldshtein

  • 1Institute of Imunology, USSR Ministry of Health, Moscow.

Brain, Behavior, and Immunity
|March 1, 1988
PubMed

It was shown that increases of cAMP levels before and after adrenaline (10(-6) mol/liter) and cAMP levels before and after acetylcholine (10(-6) mol/liter) occur in mouse spleen B-lymphocytes in 2-3 and 3-6 days, respectively, after immunization with ovalbumin. Using radiolabeled blockers of these neuroreceptors, it was shown that their receptors on B-lymphocytes increase 3 and 3-4 days, respectively, after immunization. The data indicate that increases of spleen B-lymphocyte reactivity to neuromediators occur during an immune reaction associated, in part, with increases in the expression of their receptors.

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