One-single physical exercise session after object recognition learning promotes memory persistence through hippocampal noradrenergic mechanisms
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Updated: Mar 3, 2026

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis
Published on: August 20, 2020
Liane da Silva de Vargas1, Ben-Hur Souto das Neves1, Rafael Roehrs2
1Physiology Research Group, Federal University of Pampa, Uruguaiana, RS, Brazil.
Abstract:
Previously we showed the involvement of the hippocampal noradrenergic system in the consolidation and persistence of object recognition (OR) memory. Here we show that one-single physical exercise session performed immediately after learning promotes OR memory persistence and increases norepinephrine levels in the hippocampus. Additionally, effects of exercise on memory are avoided by an intra-hippocampal beta-adrenergic antagonist infusion. Taken together, these results suggest that exercise effects on memory can be related to noradrenergic mechanisms and acute physical exercise can be a non-pharmacological intervention to assist memory consolidation and persistence, with few or no side effects.
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