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A MRI-Based Toolbox for Neurosurgical Planning in Nonhuman Primates

A MRI-Based Toolbox for Neurosurgical Planning in Nonhuman Primates

Published on: July 17, 2020

A population MRI brain template and analysis tools for the macaque.

Jakob Seidlitz¹, Caleb Sponheim², Daniel Glen³

¹Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD 20892, USA; Developmental Neurogenomics Unit, National Institute of Mental Health, Bethesda, MD 20892, USA; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge CB2 1TN, UK.

|May 3, 2017

Summary

A new high-resolution macaque brain template, the National Institute of Mental Health Macaque Template (NMT), offers improved neuroimaging analysis. This tool standardizes processing for individual subjects, enhancing data comparison across studies.

Keywords:

Atlas MRI Macaque Segmentation Template Vasculature

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Last Updated: Mar 3, 2026

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Serial Two-Photon Tomography of the Whole Marmoset Brain for Neuroanatomical Analyses

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Published on: January 17, 2025

Area of Science:

Neuroimaging
Primate Neuroscience
Comparative Anatomy

Background:

Standard anatomical templates are crucial for human neuroimaging analysis and cross-study comparisons.
Existing non-human primate in vivo templates lack sufficient contrast and automated processing tools.

Purpose of the Study:

Introduce the National Institute of Mental Health Macaque Template (NMT) for high-resolution in vivo macaque brain imaging.
Provide tools for automated single-subject processing and enhanced data visualization.

Main Methods:

Generated a high-resolution in vivo MRI template of the average macaque brain from 31 subjects.
Created tissue segmentation and cortical thickness maps from the NMT volume.
Developed an analysis pipeline for automated brain extraction, segmentation, and morphometric analysis.

Main Results:

The NMT provides a high-resolution average macaque brain template.
Generated associated tools including tissue segmentation, cortical thickness maps, and surface reconstructions.
An automated analysis pipeline standardizes neuroimaging processing for individual macaque subjects.

Conclusions:

The NMT and its associated tools offer a standardized platform for macaque neuroimaging.
Facilitates precise single-subject data analysis and robust cross-study characterization of neuroimaging results.
Improves the reliability and efficiency of non-human primate brain analysis.