Vitamin D endocrinology on the cross-road between immunity and metabolism

The effects of vitamin D on the immune function have been recognized for more than a quarter of a century. However, our understanding of the multifactorial nature of the effects of vitamin D at the cellular, molecular and metabolic level in different immune cells of the innate and adaptive immune system has dramatically progressed during the last decades. In this review, we summarize the main metabolic pathways preferentially used in different subsets of macrophages, dendritic cells, T and B cells as well as the immunomodulatory effects of vitamin D on these cells. We will highlight the metabolic reprogramming happening in vitamin D-conditioned tolerogenic dendritic cells. A better knowledge of the dynamics of metabolic states in immune subsets and their possible roles in inflammation and autoimmunity may advance the development of novel immunotherapies. Likewise, the implications of effects of vitamin D on immunometabolism may progress our insights in the nature of immune responses in health and disease.