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Updated: Mar 3, 2026
09:35
Dispersion of Nanomaterials in Aqueous Media: Towards Protocol Optimization
Published on: December 25, 2017
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Dispersion and stabilization of cochleate nanoparticles
Tamás Bozó1, András Wacha2, Judith Mihály2
1Semmelweis University, Department of Biophysics and Radiation Biology, Tűzoltó u. 37-47, 1094 Budapest, Hungary.
Summary
Citric acid effectively disperses aggregated cochleates, enabling their use as a drug delivery system. This method stabilizes cochleate nanoparticles for long-term storage while preserving their structure.
Area of Science:
- Nanotechnology
- Biomedical Engineering
- Materials Science
Background:
- Cochleates are nanoscale membrane rolls for drug delivery.
- They protect encapsulated materials from degradation.
- Self-aggregation hinders cochleate-based drug delivery system development.
Purpose of the Study:
- To address cochleate self-aggregation.
- To develop a stable cochleate drug delivery system.
Main Methods:
- Transient addition of citric acid within a specific concentration range.
- Analysis of cochleate dispersion, stability, and ultrastructure.
Main Results:
- Citric acid effectively disperses cochleate aggregates.
- The disperse state is stabilized for long-term storage.
- Cochleate nanoparticle ultrastructure and topology are preserved.
Conclusions:
- Citric acid is a key agent for overcoming cochleate aggregation.
- This finding facilitates the development of efficient cochleate drug delivery systems.
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