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Related Experiment Video

Updated: Mar 3, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

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Risk models for patients with localised renal cell carcinoma.

J M Velis1, F J Ancizu1, M Hevia1

  • 1Departamento de Urología, Clínica Universidad de Navarra, Pamplona, España.

Actas Urologicas Espanolas
|May 3, 2017
PubMed
Summary

For localized renal cell carcinoma (RCC), advanced Furhman grade, tumor necrosis, and invasion impact disease-free survival (DFS) and cancer-specific survival (CSS). Other factors like hematuria also influence DFS.

Keywords:
Carcinoma células renalesFactores pronósticoModelo de riesgo renalPrognostic factorsRenal cell carcinomaRenal risk model

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Area of Science:

  • Urology
  • Oncology
  • Nephrology

Background:

  • Retrospective analysis of localized renal cell carcinoma (RCC) cases.
  • Assessment of factors influencing disease-free survival (DFS) and cancer-specific survival (CSS).
  • Development of novel risk stratification groups for localized RCC.

Purpose of the Study:

  • To identify clinical-pathological variables affecting DFS and CSS in localized RCC.
  • To create predictive risk groups for DFS and CSS in localized RCC patients.

Main Methods:

  • Retrospective analysis of 596 patients with localized RCC (clear cell, papillary, or chromophobe) from January 1990 to December 2012.
  • Utilized Cox regression models to analyze clinical-pathological variables impacting DFS and CSS.
  • Designed risk groups based on identified prognostic variables.

Main Results:

  • Median follow-up was 5.96 years; 18.8% experienced recurrence.
  • DFS rates at 5, 10, and 15 years were 82%, 77%, and 72%.
  • Independent DFS predictors: Furhman grade 3-4, hematuria, lymphocytic/vascular invasion, tumor necrosis, pT3-pT4 stage.
  • Cancer-specific survival (CSS) rates at 5, 10, and 15 years were 92%, 86%, and 83%; 9.6% died from RCC.
  • Independent CSS predictors: Furhman grade 3-4, perinephric fat invasion, tumor necrosis.

Conclusions:

  • Localized RCC prognosis depends on factors beyond pT3-pT4 stage, including hematuria and invasion for DFS.
  • Furhman grade 3-4 and tumor necrosis are critical predictors for both DFS and CSS in localized RCC.