Polyphenotypic Psoriasis: A Report from the GRAPPA 2016 Annual Meeting

Area of Science:

• Dermatology
• Immunology
• Systemic Inflammatory Diseases

Background:

• Psoriasis is a complex systemic inflammatory disease with diverse clinical presentations.
• Current groundbreaking therapies target specific pathways but often exclude patients with nonplaque psoriasis phenotypes.
• This exclusion leads to undertreatment for a significant patient population due to restrictive eligibility criteria.

Purpose of the Study:

• To propose a unifying term, "polyphenotypic psoriasis," to encompass all psoriasis subtypes.
• To advocate for broader inclusion criteria for novel psoriasis therapies.
• To enhance clinical awareness of psoriasis's heterogeneous manifestations beyond chronic plaque psoriasis.

Main Methods:

• Conceptual framework development.
• Literature review on psoriasis phenotypes and current therapeutic targets.
• Clinical observation analysis.

Main Results:

• The proposed term "polyphenotypic psoriasis" effectively describes both plaque and nonplaque subtypes.
• It also accounts for patients with single or multiple phenotype involvement.
• This terminology aims to broaden the scope of patients eligible for advanced treatments.

Conclusions:

• Adoption of "polyphenotypic psoriasis" can help overcome treatment disparities.
• Recognizing the full spectrum of psoriasis manifestations is crucial for effective patient management.
• This approach encourages a more inclusive strategy for developing and applying novel psoriasis therapies.