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Updated: Mar 3, 2026

A Rapid In Vivo Bioassay for Developmentally Active Enhancers
Mapping the D.melanogaster En1A Enhancer Modules Responsible for Transcription Activation and Long-Distance
L S Melnikova1, E A Pomerantseva1, V V Molodina1
1Institute of Gene Biology, Russian Academy of Sciences, Vavilova str. 34/5, Moscow, 119334, Russia.
Abstract:
The structure of the new enhancer En1A of the 1A region of the X chromosome of D. melanogaster was investigated. Two distinct regulatory elements were found. The first element is responsible for transcription activation, and the second element provides specific interaction with the promoter of the yellow gene. The findings support the hypothesis of a modular structure for enhancers, including certain sequences that bind transcription activators and special communication elements providing long-distance enhancer-promoter interaction.
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