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Published on: August 13, 2019
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Sinus augmentation using rhBMP-2-loaded synthetic bone substitute with simultaneous implant placement in rabbits
Myung-Jae Joo1, Jae-Kook Cha1, Hyun-Chang Lim2
1Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Korea.
Journal of Periodontal & Implant Science
|May 3, 2017
Summary
Recombinant human bone morphogenetic protein-2 (rhBMP-2) enhanced sinus augmentation, leading to greater new bone formation and improved implant osseointegration in rabbits. This demonstrates rhBMP-2
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Dental Implantology
Background:
- Sinus augmentation is crucial for dental implant placement in the posterior maxilla.
- Limited bone height presents challenges for simultaneous implant placement and augmentation.
- rhBMP-2 shows potential to enhance bone regeneration.
Purpose of the Study:
- To evaluate the efficacy of rhBMP-2 loaded synthetic bone substitute in sinus augmentation.
- To assess the impact on simultaneous implant osseointegration in rabbits.
Main Methods:
- Rabbits underwent sinus augmentation with rhBMP-2 loaded or saline soaked synthetic bone substitute.
- Implants were placed simultaneously with the augmentation procedure.
- Micro-CT and histological analyses were performed after 4 weeks.
Main Results:
- Significantly greater newly formed bone volume in the rhBMP-2 group (51.6 mm³) compared to control (46.6 mm³).
- Enhanced osseointegration height at the implant's medial surface in the rhBMP-2 group (5.2 mm) versus control (4.3 mm).
Conclusions:
- rhBMP-2 loaded synthetic bone substitute promotes successful osseointegration during sinus augmentation.
- Effective bone regeneration is achievable even with limited initial bone height.
