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Physiological indices for the categorization of Mibyeong severity
Kyung Eun Lee1, Joong Jae Kim1, Hee-Jeong Jin2
1Department of Mechanical and Biomedical Engineering, Kangwon National University, Chuncheon, Korea.
Integrative Medicine Research
|May 3, 2017
Summary
Mibyeong severity can be categorized using novel cardiovascular indices. Lower vascular resistance and higher capacitance correlate with increased Mibyeong severity, aiding in diagnosis.
Area of Science:
- Cardiovascular Physiology
- Biomedical Engineering
- Integrative Medicine
Background:
- Mibyeong (pre-disease) diagnosis remains challenging due to unclear severity indices.
- Existing research lacks a simple, clear method for categorizing Mibyeong severity.
- Hypothesis: Severe Mibyeong involves reduced physiological function, activating homeostasis and altering vascular dynamics.
Purpose of the Study:
- To develop and validate novel cardiovascular indices for Mibyeong severity categorization.
- To investigate the relationship between vascular resistance, capacitance, and Mibyeong severity.
- To establish a more objective method for identifying and assessing Mibyeong.
Main Methods:
- Utilized a simple cardiovascular system model to analyze vascular resistance and capacitance.
- Optimally fitted the model to measured systolic and diastolic pressures, heart rate, and age.
- Derived novel indices based on cardiovascular parameters to quantify Mibyeong severity.
Main Results:
- Analysis of 509 individuals supported the hypothesis.
- Lower vascular resistance was observed in individuals with severe Mibyeong.
- Vascular resistance decreased, while vascular capacitance increased with escalating Mibyeong severity.
Conclusions:
- Novel indices for Mibyeong severity categorization were successfully derived and tested.
- Epidemiological analysis confirmed that decreasing vascular resistance and increasing capacitance are valid indicators of Mibyeong severity.
- These findings offer a promising approach for objective Mibyeong assessment.
